| EC |
1.5.1.31 |
| Accepted name: |
berberine reductase |
| Reaction: |
(R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+ |
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For diagram of canadine biosynthesis, click here |
| Other name(s): |
(R)-canadine synthase |
| Systematic name: |
(R)-tetrahydroberberine:NADP+ oxidoreductase |
| Comments: |
Involved in alkaloid biosynthesis in Corydalis cava to give (R)-canadine with the opposite configuration to the precursor of berberine (see EC 1.3.3.8 tetrahydroberberine oxidase). Also acts on 7,8-dihydroberberine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Bauer, W. and Zenk, M.H. Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro. Tetrahedron Lett. 32 (1991) 487–490. |
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| [EC 1.5.1.31 created 2002] |
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