| EC |
1.5.1.50 |
| Accepted name: |
dihydromonapterin reductase |
| Reaction: |
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+ |
| Glossary: |
7,8-dihydromonapterin = 2-amino-6-[(1S,2S)-1,2,3-trihydroxypropyl]-7,8-dihydropteridin-4(3H)-one |
| Other name(s): |
FolM; H2-MPt reductase |
| Systematic name: |
5,6,7,8-tetrahydromonapterin:NADP+ oxidoreductase |
| Comments: |
The enzyme, found in many Gram negative bacteria, also slowly reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase). The enzyme has no activity with NADH. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Pribat, A., Blaby, I.K., Lara-Nunez, A., Gregory, J.F., 3rd, de Crecy-Lagard, V. and Hanson, A.D. FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa. J. Bacteriol. 192 (2010) 475–482. [DOI] [PMID: 19897652] |
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| [EC 1.5.1.50 created 2015] |
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