ExplorEnz: EC 1.5.1.55

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1.5.1.55

Accepted name:

carboxyaminopropylagmatine dehydrogenase

Reaction:

N¹-[(S)-3-amino-3-carboxypropyl]agamatine + NADP⁺ + H₂O = agmatine + L-aspartate 4-semialdehyde + NADPH + H⁺

Glossary:

N¹-[(S)-3-amino-3-carboxypropyl]agamatine = carboxyaminopropylagmatine
L-aspartate 4-semialdehyde = L-aspartate β-semialdehyde

Other name(s):

slr0049 (locus name)

Systematic name:

N¹-[(S)-2-aminobutanoate]agmatine:NADP⁺ oxidoreductase (agmatine-forming)

Comments:

The enzyme, characterized from the cyanobacterium Synechocystis sp. PCC 6803, catalyses the reductive condensation of agmatine and L-aspartate 4-semialdehyde. It participates in a biosynthetic pathway for spermidine.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Xi, H., Nie, X., Gao, F., Liang, X., Li, H., Zhou, H., Cai, Y. and Yang, C. A bacterial spermidine biosynthetic pathway via carboxyaminopropylagmatine. Sci Adv 9:eadj9075 (2023). [DOI] [PMID: 37878710]

[EC 1.5.1.55 created 2024]