ExplorEnz: EC 1.5.1.57

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1.5.1.57

Accepted name:

18-hydroxynorfluorocurarine reductase

Reaction:

17,18-epoxy-17-hydroxycur-19-ene + NADP⁺ = 18-hydroxynorfluorocurarine + NADPH + H⁺

Glossary:

17,18-epoxy-17-hydroxycur-19-ene = (19E)-18-hydroxycur-19-en-17-al = Wieland-Gumlich aldehyde
norfluorocurarine = (19E)-cura-2(16),19-dien-17-al

Other name(s):

Wieland-Gumlich aldehyde synthase

Systematic name:

17,18-epoxy-17-hydroxycur-19-ene:NADP⁺ oxidoreductase

Comments:

The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of strychnine. It belongs to the family of medium-chain dehydrogenase/reductases (MDRs). The enzyme forms an aldehyde group at C-17, which results in spontaneous cyclization. In vitro the enzyme can also act on norfluorocurarine, but more slowly.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Hong, B., Grzech, D., Caputi, L., Sonawane, P., Lopez, C.ER., Kamileen, M.O., Hernandez Lozada, N.J., Grabe, V. and O'Connor, S.E. Biosynthesis of strychnine. Nature 607 (2022) 617–622. [DOI] [PMID: 35794473]

[EC 1.5.1.57 created 2024]