EC |
1.5.1.7 |
Accepted name: |
saccharopine dehydrogenase (NAD+, L-lysine-forming) |
Reaction: |
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+ |
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For diagram of lysine catabolism, click here and for diagram of L-lysine synthesis, click here |
Glossary: |
L-saccharopine = N6-(L-1,3-dicarboxypropyl)-L-lysine |
Other name(s): |
lysine-2-oxoglutarate reductase; dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming); ε-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming); N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming); 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming) |
Systematic name: |
N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming) |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9073-96-5 |
References: |
1. |
Fujioka, M. and Nakatani, Y. Saccharopine dehydrogenase. Interaction with substrate analogues. Eur. J. Biochem. 25 (1972) 301–307. [DOI] [PMID: 4339117] |
2. |
Saunders, P.P. and Broquist, H.P. Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase. J. Biol. Chem. 241 (1966) 3435–3440. [PMID: 4287986] |
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[EC 1.5.1.7 created 1972] |
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