ExplorEnz: EC 1.5.1.9

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1.5.1.9

Accepted name:

saccharopine dehydrogenase (NAD⁺, L-glutamate-forming)

Reaction:

N⁶-(L-1,3-dicarboxypropyl)-L-lysine + NAD⁺ + H₂O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H⁺

Glossary:

saccharopine = N⁶-(L-1,3-dicarboxypropyl)-L-lysine
(S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine

Other name(s):

dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming); saccharopin dehydrogenase; NAD⁺ oxidoreductase (L-2-aminoadipic-δ-semialdehyde and glutamate forming); aminoadipic semialdehyde synthase; 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD⁺ oxidoreductase (L-glutamate-forming)

Systematic name:

N⁶-(L-1,3-dicarboxypropyl)-L-lysine:NAD⁺ oxidoreductase (L-glutamate-forming)

Comments:

The activities of this enzyme along with EC 1.5.1.8, saccharopine dehydrogenase (NADP⁺, L-lysine-forming), occur on a single protein.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37256-26-1

References:

1.	Hutzler, J. and Dancis, J. Conversion of lysine to saccharopine by human tissues. Biochim. Biophys. Acta 158 (1968) 62–69. [DOI] [PMID: 4385118]
2.	Markovitz, P.J., Chuang, D.T. and Cox, R.P. Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities. J. Biol. Chem. 259 (1984) 11643–11646. [PMID: 6434529]

[EC 1.5.1.9 created 1972, modified 2011]