| EC |
1.5.3.21 |
| Accepted name: |
4-methylaminobutanoate oxidase (methylamine-forming) |
| Reaction: |
4-methylaminobutanoate + O2 + H2O = succinate semialdehyde + methylamine + H2O2 |
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For diagram of nicotine catabolism by arthrobacter, click here |
| Other name(s): |
mao (gene name, ambiguous) |
| Systematic name: |
4-methylaminobutanoate methylamidohydrolase |
| Comments: |
The enzyme participates in the nicotine degradation pathway of the soil bacterium Arthrobacter nicotinovorans. Has a very weak monoamine oxidase (EC 1.4.3.4) activity with 4-aminobutanoate [1]. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Chiribau, C.B., Sandu, C., Fraaije, M., Schiltz, E. and Brandsch, R. A novel γ-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1. Eur. J. Biochem. 271 (2004) 4677–4684. [DOI] [PMID: 15606755] |
| 2. |
Chiribau, C.B., Mihasan, M., Ganas, P., Igloi, G.L., Artenie, V. and Brandsch, R. Final steps in the catabolism of nicotine. FEBS J. 273 (2006) 1528–1536. [DOI] [PMID: 16689938] |
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| [EC 1.5.3.21 created 2012] |
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