ExplorEnz: EC 1.5.3.22

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1.5.3.22

Accepted name:

coenzyme F₄₂₀H₂ oxidase

Reaction:

2 reduced coenzyme F₄₂₀ + O₂ = 2 oxidized coenzyme F₄₂₀ + 2 H₂O

For diagram of coenzyme F₄₂₀ biosynthesis, click here

Glossary:

oxidized coenzyme F₄₂₀ = N-(N-{O-[5-(8-hydroxy-2,4-dioxo-2,3,4,10-tetrahydropyrimido[4,5-b]quinolin-10-yl)-5-deoxy-L-ribityl-1-phospho]-(S)-lactyl}-γ-L-glutamyl)-L-glutamate

Other name(s):

FprA

Systematic name:

reduced coenzyme F₄₂₀:oxygen oxidoreductase

Comments:

The enzyme contains FMN and a binuclear iron center. The enzyme from the archaeon Methanothermobacter marburgensis is Si-face specific with respect to C-5 of coenzyme F₄₂₀ [2].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Seedorf, H., Dreisbach, A., Hedderich, R., Shima, S. and Thauer, R.K. F₄₂₀H₂ oxidase (FprA) from Methanobrevibacter arboriphilus, a coenzyme F₄₂₀-dependent enzyme involved in O₂ detoxification. Arch. Microbiol. 182 (2004) 126–137. [DOI] [PMID: 15340796]
2.	Seedorf, H., Kahnt, J., Pierik, A.J. and Thauer, R.K. Si-face stereospecificity at C5 of coenzyme F₄₂₀ for F₄₂₀H₂ oxidase from methanogenic Archaea as determined by mass spectrometry. FEBS J. 272 (2005) 5337–5342. [DOI] [PMID: 16218963]
3.	Seedorf, H., Hagemeier, C.H., Shima, S., Thauer, R.K., Warkentin, E. and Ermler, U. Structure of coenzyme F₄₂₀H₂ oxidase (FprA), a di-iron flavoprotein from methanogenic Archaea catalyzing the reduction of O₂ to H₂O. FEBS J. 274 (2007) 1588–1599. [DOI] [PMID: 17480207]

[EC 1.5.3.22 created 2013]