| EC |
1.5.5.3 |
| Accepted name: |
hydroxyproline dehydrogenase |
| Reaction: |
trans-4-hydroxy-L-proline + a quinone = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol |
| Other name(s): |
HYPDH; OH-POX; hydroxyproline oxidase; PRODH2 (gene name) |
| Systematic name: |
trans-4-hydroxy-L-proline:quinone oxidoreductase |
| Comments: |
A flavoprotein (FAD). The enzyme from human also has low activity with L-proline (cf. EC 1.5.5.2, proline dehydrogenase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Cooper, S.K., Pandhare, J., Donald, S.P. and Phang, J.M. A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species. J. Biol. Chem. 283 (2008) 10485–10492. [DOI] [PMID: 18287100] |
| 2. |
Summitt, C.B., Johnson, L.C., Jonsson, T.J., Parsonage, D., Holmes, R.P. and Lowther, W.T. Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria. Biochem. J. 466 (2015) 273–281. [DOI] [PMID: 25697095] |
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| [EC 1.5.5.3 created 2017] |
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