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Your query returned 1 entry. Printable version
EC | 1.5.7.3 | ||||
Accepted name: | N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin) | ||||
Reaction: | (1) N,N-dimethylglycine + 2 oxidized ferredoxin + H2O = sarcosine + formaldehyde + 2 reduced ferredoxin + 2 H+ (2) sarcosine + 2 oxidized ferredoxin + H2O = glycine + formaldehyde + 2 reduced ferredoxin + 2 H+ |
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Other name(s): | ddhC (gene name); dgcA (gene name) | ||||
Systematic name: | N,N-dimethylglycine/sarcosine:ferredoxin oxidoreductase (demethylating) | ||||
Comments: | This bacterial enzyme is involved in degradation of glycine betaine. The enzyme contains non-covalently bound FAD and NAD(P) cofactors, and catalyses the demethylation of both N,N-dimethylglycine and sarcosine, releasing formaldehyde and forming glycine as the final product. The enzyme can utilize both NAD+ and NADP+, but the catalytic efficiency with NAD+ is ~5-fold higher. The native electron acceptor of the enzyme is a membrane-bound clostridial-type ferredoxin, which transfers the electrons to an electron-transfer flavoprotein (ETF). | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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