| EC |
1.5.8.3 |
| Accepted name: |
sarcosine dehydrogenase |
| Reaction: |
sarcosine + 5,6,7,8-tetrahydrofolate + oxidized [electron-transfer flavoprotein] = glycine + 5,10-methylenetetrahydrofolate + reduced [electron-transfer flavoprotein] |
| Other name(s): |
sarcosine N-demethylase; monomethylglycine dehydrogenase; sarcosine:(acceptor) oxidoreductase (demethylating); sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating) |
| Systematic name: |
sarcosine, 5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming) |
| Comments: |
A flavoprotein (FMN) found in eukaryotes. In the absence of tetrahydrofolate the enzyme produces formaldehyde. cf. EC 1.5.3.1, sarcosine oxidase (formaldehyde-forming), and EC 1.5.3.24, sarcosine oxidase (5,10-methylenetetrahydrofolate-forming). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 37228-65-2, 93389-49-2 |
| References: |
| 1. |
Hoskins, D.D. and MacKenzie, C.G. Solubilization and electron transfer flavoprotein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase. J. Biol. Chem. 236 (1961) 177–183. [DOI] [PMID: 13716069] |
| 2. |
Frisell, W.R. and MacKenzie, C.G. Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase. J. Biol. Chem. 237 (1962) 94–98. [DOI] [PMID: 13895406] |
| 3. |
Wittwer, A.J. and Wagner, C. Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins. J. Biol. Chem. 256 (1981) 4109–4115. [DOI] [PMID: 6163778] |
| 4. |
Steenkamp, D.J. and Husain, M. The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases. Biochem. J. 203 (1982) 707–715. [DOI] [PMID: 6180732] |
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| [EC 1.5.8.3 created 1972 as EC 1.5.99.1, transferred 2012 to EC 1.5.8.3, modified 2022] |
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