ExplorEnz: EC 1.5.98.2

Your query returned 1 entry. Printable version

1.5.98.2

Accepted name:

5,10-methylenetetrahydromethanopterin reductase

Reaction:

5-methyltetrahydromethanopterin + oxidized coenzyme F₄₂₀ = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F₄₂₀

For diagram of methane biosynthesis, click here

Other name(s):

5,10-methylenetetrahydromethanopterin cyclohydrolase; N⁵,N¹⁰-methylenetetrahydromethanopterin reductase; methylene-H₄MPT reductase; coenzyme F₄₂₀-dependent N⁵,N¹⁰-methenyltetrahydromethanopterin reductase; N⁵,N¹⁰-methylenetetrahydromethanopterin:coenzyme-F₄₂₀ oxidoreductase

Systematic name:

5-methyltetrahydromethanopterin:coenzyme-F₄₂₀ oxidoreductase

Comments:

Catalyses an intermediate step in methanogenesis from CO₂ and H₂ in methanogenic archaea.

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Ma, K. and Thauer, R.K. Purification and properties of N⁵,N¹⁰-methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (strain Marburg). Eur. J. Biochem. 191 (1990) 187–193. [DOI] [PMID: 2379499]
2.	te Brömmelstroet, B.W., Geerts, W.J., Keltjens, J.T., van der Drift, C. and Vogels, G.D. Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F₄₂₀-dependent enzymes, from Methanosarcina barkeri. Biochim. Biophys. Acta 1079 (1991) 293–302. [DOI] [PMID: 1911853]
3.	Ma, K. and Thauer, R.K. Single step purification of methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum by specific binding to blue sepharose CL-6B. FEBS Lett. 268 (1990) 59–62. [DOI] [PMID: 1696553]
4.	te Brömmelstroet, B.W., Hensgens, C.M., Keltjens, J.T., van der Drift, C. and Vogels, G.D. Purification and properties of 5,10-methylenetetrahydromethanopterin reductase, a coenzyme F₄₂₀-dependent enzyme, from Methanobacterium thermoautotrophicum strain ΔH. J. Biol. Chem.* 265 (1990) 1852–1857. [PMID: 2298726]
5.	te Brömmelstroet, B.W., Hensgens, C.M., Geerts, W.J., Keltjens, J.T., van der Drift, C. and Vogels, G.D. Purification and properties of 5,10-methenyltetrahydromethanopterin cyclohydrolase from Methanosarcina barkeri. J. Bacteriol. 172 (1990) 564–571. [DOI] [PMID: 2298699]

[EC 1.5.98.2 created 2000 as EC 1.5.99.11, modified 2004, transferred to EC 1.5.98.2 2014]