| EC |
1.5.99.15 |
| Accepted name: |
dihydromethanopterin reductase (acceptor) |
| Reaction: |
5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor |
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For diagram of methanopterin biosynthesis (part 4), click here |
| Other name(s): |
DmrX |
| Systematic name: |
5,6,7,8-tetrahydromethanopterin:acceptor 5,6-oxidoreductase |
| Comments: |
This archaeal enzyme catalyses the last step in the biosynthesis of tetrahydromethanopterin, a folate analogue used in methanogenesis. The enzyme, characterized from the archaea Methanosarcina mazei and Methanocaldococcus jannaschii, is an iron-sulfur flavoprotein. cf. EC 1.5.1.47, dihydromethanopterin reductase [NAD(P)+]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Wang, S., Tiongson, J. and Rasche, M.E. Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei. J. Bacteriol. 196 (2014) 203–209. [DOI] [PMID: 23995635] |
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| [EC 1.5.99.15 created 2014] |
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