| EC |
1.5.99.6 |
| Accepted name: |
spermidine dehydrogenase |
| Reaction: |
spermidine + acceptor + H2O = propane-1,3-diamine + 4-aminobutanal + reduced acceptor |
| Glossary: |
spermidine = N-(3-aminopropyl)butane-1,4-diamine |
| Other name(s): |
spermidine:(acceptor) oxidoreductase |
| Systematic name: |
spermidine:acceptor oxidoreductase |
| Comments: |
A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol and cytochrome c can act as acceptor. 4-Aminobutanal condenses non-enzymically to 1-pyrroline. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9076-64-6 |
| References: |
| 1. |
Tabor, C.W. and Kellogg, P.D. Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens. J. Biol. Chem. 245 (1970) 5424–5433. [PMID: 4918845] |
| 2. |
Tabor, H. and Tabor, C.W. Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase. Adv. Enzymol. Relat. Areas Mol. Biol. 36 (1972) 225–226. |
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| [EC 1.5.99.6 created 1976] |
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