ExplorEnz: EC 1.6.3.5

Your query returned 1 entry. Printable version

1.6.3.5

Accepted name:

renalase

Reaction:

(1) 1,2-dihydro-β-NAD(P) + H⁺ + O₂ = β-NAD(P)⁺ + H₂O₂
(2) 1,6-dihydro-β-NAD(P) + H⁺ + O₂ = β-NAD(P)⁺ + H₂O₂

Other name(s):

αNAD(P)H oxidase/anomerase (incorrect); NAD(P)H:oxygen oxidoreductase (H₂O₂-forming, epimerising) (incorrect)

Systematic name:

dihydro-NAD(P):oxygen oxidoreductase (H₂O₂-forming)

Comments:

Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of β-NAD(P)H back to β-NAD(P)⁺. These isomeric forms, generated by nonspecific reduction of β-NAD(P)⁺ or by tautomerization of β-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Xu, J., Li, G., Wang, P., Velazquez, H., Yao, X., Li, Y., Wu, Y., Peixoto, A., Crowley, S. and Desir, G.V. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. J. Clin. Invest. 115 (2005) 1275–1280. [DOI] [PMID: 15841207]
2.	Beaupre, B.A., Hoag, M.R., Roman, J., Forsterling, F.H. and Moran, G.R. Metabolic function for human renalase: oxidation of isomeric forms of β-NAD(P)H that are inhibitory to primary metabolism. Biochemistry 54 (2015) 795–806. [DOI] [PMID: 25531177]

[EC 1.6.3.5 created 2014, modified 2015]