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Your query returned 1 entry. Printable version
EC | 1.7.1.13 | ||||||||||||
Accepted name: | preQ1 synthase | ||||||||||||
Reaction: | 7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+ | ||||||||||||
For diagram of queuine biosynthesis, click here | |||||||||||||
Glossary: | 7-aminomethyl-7-carbaguanine = preQ1 = 7-aminomethyl-7-deazaguanine 7-cyano-7-carbaguanine = preQ0 = 7-cyano-7-deazaguanine |
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Other name(s): | YkvM; QueF; preQ0 reductase; preQ0 oxidoreductase; 7-cyano-7-deazaguanine reductase; queuine synthase (incorrect as queuine is not the product); queuine:NADP+ oxidoreductase (incorrect as queuine is not the product) | ||||||||||||
Systematic name: | 7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase | ||||||||||||
Comments: | The reaction occurs in the reverse direction. This enzyme catalyses one of the early steps in the synthesis of queuosine (Q-tRNA), and is followed by the action of EC 2.4.2.29, tRNA-guanosine34 transglycosylase. Queuosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria [2] and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 1256460-80-6 | ||||||||||||
References: |
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