ExplorEnz: EC 1.7.1.7

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1.7.1.7

Accepted name:

GMP reductase

Reaction:

IMP + NH₃ + NADP⁺ = GMP + NADPH + H⁺

Glossary:

IMP = inosine 5′-phosphate
GMP = guanosine 5′-phosphate

Other name(s):

guanosine 5′-monophosphate reductase; NADPH:GMP oxidoreductase (deaminating); guanosine monophosphate reductase; guanylate reductase; NADPH₂:guanosine-5′-phosphate oxidoreductase (deaminating); guanosine 5′-phosphate reductase

Systematic name:

inosine-5′-phosphate:NADP⁺ oxidoreductase (aminating)

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9029-32-7

References:

1.	MacKenzie, J.J. and Sorensen, L.B. Guanosine 5′-phosphate reductase of human erythrocytes. Biochim. Biophys. Acta 327 (1973) 282–294. [DOI] [PMID: 4149840]
2.	Mager, J. and Magasanik, B. Guanosine 5′-phosphate reductase and its role in the interconversion of purine nucleotides. J. Biol. Chem. 235 (1960) 1474–1478. [PMID: 14419794]

[EC 1.7.1.7 created 1965 as EC 1.6.6.8, transferred 2002 to EC 1.7.1.7]