| EC |
1.7.1.9 |
| Accepted name: |
nitroquinoline-N-oxide reductase |
| Reaction: |
4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+ |
| Other name(s): |
4-nitroquinoline 1-oxide reductase; 4NQO reductase; NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase |
| Systematic name: |
4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37256-35-2 |
| References: |
| 1. |
Toriyama, N. [Metabolism of quinoline derivatives. On the reducing enzyme of 4-nitroquinoline-N-oxide] Nichidai Igaku Zasshi 24 (1965) 423–432. (in Japanese) |
| 2. |
Stanley, J.S., York, J.L. and Benson, A.M. Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice. Cancer Res. 52 (1992) 58–63. [PMID: 1370076] |
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| [EC 1.7.1.9 created 1972 as EC 1.6.6.10, transferred 2002 to EC 1.7.1.9] |
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