The Enzyme Database

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Accepted name: nitrite dismutase
Reaction: 3 nitrite + 2 H+ = 2 nitric oxide + nitrate + H2O
Other name(s): Prolixin S; Nitrophorin 7
Systematic name: nitrite:nitrite oxidoreductase
Comments: Contains ferriheme b. The enzyme is one of the nitrophorins from the salivary gland of the blood-feeding insect Rhodnius prolixus. Nitric oxide produced induces vasodilation after injection. Nitrophorins 2 and 4 can also catalyse this reaction.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  He, C. and Knipp, M. Formation of nitric oxide from nitrite by the ferriheme b protein nitrophorin 7. J. Am. Chem. Soc. 131 (2009) 12042–12043. [DOI] [PMID: 19655755]
2.  He, C., Ogata, H. and Knipp, M. Formation of the complex of nitrite with the ferriheme b β-barrel proteins nitrophorin 4 and nitrophorin 7. Biochemistry 49 (2010) 5841–5851. [DOI] [PMID: 20524697]
[EC created 2011]

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