The Enzyme Database

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Accepted name: glutathione-disulfide reductase
Reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
For diagram of glutathione biosynthesis, click here
Glossary: The term ’oxidized glutathione’ has been replaced by the term ’glutathione disulfide’ as the former is ambiguous. S,S′-Biglutathione may also be used to refer to this compound.
Other name(s): glutathione reductase; glutathione reductase (NADPH); NADPH-glutathione reductase; GSH reductase; GSSG reductase; NADPH-GSSG reductase; glutathione S-reductase; NADPH:oxidized-glutathione oxidoreductase
Systematic name: glutathione:NADP+ oxidoreductase
Comments: A dimeric flavoprotein (FAD); activity is dependent on a redox-active disulfide in each of the active centres.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9001-48-3
1.  Pai, E.F., Schirmer, R.H. and Schulz, G.E. Structural studies on crystalline glutathione reductase from human erythrocytes. In: Singer, T.P. and Ondarza, R.N. (Ed.), Mechanisms of Oxidizing Enzymes, Mechanisms of Oxidizing Enzymes, New York, 1978, pp. 17–22.
2.  Pigiet, V.P. and Conley, R.R. Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography. J. Biol. Chem. 252 (1977) 6367–6372. [PMID: 330529]
3.  Racker, E. Glutathione reductase from bakers' yeast and beef liver. J. Biol. Chem. 217 (1955) 855–865. [PMID: 13271446]
4.  van Heyningen, R. and Pirie, A. Reduction of glutathione coupled with oxidative decarboxylation of malate in cattle lens. Biochem. J. 53 (1953) 436–444. [PMID: 13032091]
5.  Worthington, D.J. and Rosemeyer, M.A. Glutathione reductase from human erythrocytes. Catalytic properties and aggregation. Eur. J. Biochem. 67 (1976) 231–238. [DOI] [PMID: 9277]
6.  Böhmé, C.C., Arscott, L.D., Becker, K., Schirmer, R.H. and Williams, C.H., Jr. Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme. J. Biol. Chem. 275 (2000) 37317–37323. [DOI] [PMID: 10969088]
7.  Libreros-Minotta, C.A., Pardo, J.P., Mendoza-Hernandez, G. and Rendon, J.L. Purification and characterization of glutathione reductase from Rhodospirillum rubrum. Arch. Biochem. Biophys. 298 (1992) 247–253. [DOI] [PMID: 1524433]
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