| EC |
2.1.1.102 |
| Accepted name: |
demethylmacrocin O-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin |
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For diagram of tylosin biosynthesis, click here |
| Other name(s): |
demethylmacrocin methyltransferase; DMOMT |
| Systematic name: |
S-adenosyl-L-methionine:demethylmacrocin 2′′′-O-methyltransferase |
| Comments: |
Requires Mg2+. The enzyme, isolated from the bacterium Streptomyces fradiae, is involved in the biosynthesis of the macrolide antibiotic tylosin. The 2-hydroxy group of a 6-deoxy-D-allose moiety in demethylmacrocin acts as the methyl acceptor. Also acts on demethyllactenocin, giving lactenocin. Not identical with EC 2.1.1.101 macrocin O-methyltransferase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 120313-64-6 |
| References: |
| 1. |
Kreuzman, A.J., Turner, J.R. and Yeh, W.-K. Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism. J. Biol. Chem. 263 (1988) 15626–15633. [PMID: 3170602] |
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| [EC 2.1.1.102 created 1992] |
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