The Enzyme Database

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Accepted name: 3′-hydroxy-N-methyl-(S)-coclaurine 4′-O-methyltransferase
Reaction: S-adenosyl-L-methionine + 3′-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline
For diagram of reticuline biosynthesis, click here
Systematic name: S-adenosyl-L-methionine:3′-hydroxy-N-methyl-(S)-coclaurine 4′-O-methyltransferase
Comments: Involved in isoquinoline alkaloid metabolism in plants. The enzyme has also been shown to catalyse the methylation of (RS)-laudanosoline, (S)-3′-hydroxycoclaurine and (RS)-7-O-methylnorlaudanosoline.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 132084-81-2
1.  Frenzel, T., Zenk, M.H. S-Adenosyl-L-methionine: 3′-hydroxy-N-methyl-(S)-coclaurine 4′-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway. Phytochemistry 29 (1990) 3505–3511. [DOI]
[EC created 1999]

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