The Enzyme Database

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Accepted name: columbamine O-methyltransferase
Reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine
For diagram of columbamine, palmatine and corydaline biosynthesis, click here
Systematic name: S-adenosyl-L-methionine:columbamine O-methyltransferase
Comments: The product of this reaction is a protoberberine alkaloid that is widely distributed in the plant kingdom. This enzyme is distinct in specificity from EC, 8-hydroxyquercetin 8-O-methyltransferase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 105843-76-3
1.  Rueffer, M., Amann, M., Zenk, M.H. S-Adenosyl-L-methionine:columbamine O-methyltransferase, a compartmentalized enzyme in protoberberine biosynthesis. Plant Cell Reports 3 (1986) 182–185. [DOI]
[EC created 1999]

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