| EC |
2.1.1.122 |
| Accepted name: |
(S)-tetrahydroprotoberberine N-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + an (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine |
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For diagram of canadine biosynthesis, click here, for diagram of noscapine biosynthesis, click here and for diagram of stylopine biosynthesis, click here |
| Other name(s): |
tetrahydroprotoberberine cis-N-methyltransferase |
| Systematic name: |
S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase |
| Comments: |
Involved in the biosynthesis of isoquinoline alkaloids in plants. Substrates include (S)-canadine, (S)-stylopine, and (S)-tetrahydropalmatine. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 106878-42-6 |
| References: |
| 1. |
Rueffer, M., Zumstein, G., Zenk, M.H. Partial purification and characterization of S-adenosyl-L-methionine:(S)-tetrahydroprotoberberine cis-N-methyltransferase from suspension-cultured cells of Eschscholtzia and Corydalis. Phytochemistry 29 (1990) 3727–3733. [DOI] |
| 2. |
Liscombe, D.K. and Facchini, P.J. Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy. J. Biol. Chem. 282 (2007) 14741–14751. [DOI] [PMID: 17389594] |
| 3. |
Liscombe, D.K., Ziegler, J., Schmidt, J., Ammer, C. and Facchini, P.J. Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novel N-methyltransferases from three benzylisoquinoline alkaloid-producing species. Plant J. 60 (2009) 729–743. [DOI] [PMID: 19624470] |
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| [EC 2.1.1.122 created 1999, modified 2023] |
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