| EC |
2.1.1.128 |
| Accepted name: |
(RS)-norcoclaurine 6-O-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine |
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For diagram of reticuline biosynthesis, click here |
| Glossary: |
norcoclaurine = 6,7-dihydroxy-1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline |
| Systematic name: |
S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase |
| Comments: |
The enzyme will also catalyse the 6-O-methylation of (RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 89700-33-4 |
| References: |
| 1. |
Rueffer, M., Nagakura, N., Zenk, M.H. Partial purification and properties of S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransferase from Argemone platyceras cell cultures. Planta Med. 49 (1983) 131–137. [PMID: 17405035] |
| 2. |
Sato, F., Tsujita, T., Katagiri, Y., Yoshida, S. and Yamada, Y. Purification and characterization of S-adenosyl-L-methionine:norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells. Eur. J. Biochem. 225 (1994) 125–131. [DOI] [PMID: 7925429] |
| 3. |
Stadler, R., Zenk, M.H. A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline. Liebigs Ann. Chem. (1990) 555–562. [DOI] |
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| [EC 2.1.1.128 created 1999] |
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