| EC |
2.1.1.133 |
| Accepted name: |
precorrin-4 C11-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5 |
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For diagram of corrin biosynthesis (part 3), click here |
| Other name(s): |
precorrin-3 methylase; CobM |
| Systematic name: |
S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase |
| Comments: |
In the aerobic (late cobalt insertion) cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5, and precorrin-6A, respectively. See EC 2.1.1.271, cobalt-precorrin-4 methyltransferase, for the C11-methyltransferase enzyme that participates in the anaerobic cobalamin biosynthesis pathway. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 152787-65-0 |
| References: |
| 1. |
Crouzet, J., Cameron, B., Cauchois, L., Rigault, S., Rouyez, M.C., Blanche, F. , Thibaut D., Debussche, L. Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid. J. Bacteriol. 172 (1990) 5980–5990. [DOI] [PMID: 2211521] |
| 2. |
Roth, J.R., Lawrence, J.G., Rubenfield, M., Kieffer-Higgins, S., Church, G.M. Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. J. Bacteriol. 175 (1993) 3303–3316. [DOI] [PMID: 8501034] |
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| [EC 2.1.1.133 created 1999] |
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