The Enzyme Database

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Accepted name: isoliquiritigenin 2′-O-methyltransferase
Reaction: S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2′-O-methylisoliquiritigenin
For diagram of daidzein biosynthesis, click here
Glossary: isoliquiritigenin = 4,2′,4′-trihydroxychalcone
Other name(s): chalcone OMT; CHMT
Systematic name: S-adenosyl-L-methionine:isoliquiritigenin 2′-O-methyltransferase
Comments: Not identical to EC, licodione 2′-O-methyltransferase [2]. While EC, isoliquiritigenin 2′-O-methyltransferase can use licodione as a substrate, EC cannot use isoliquiritigenin as a substrate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 139317-14-9
1.  Maxwell, C.A., Edwards, R. and Dixon, R.A. Identification, purification, and characterization of S-adenosyl-L-methionine: isoliquiritigenin 2′-O-methyltransferase from alfalfa (Medicago sativa L.). Arch. Biochem. Biophys. 293 (1992) 158–166. [DOI] [PMID: 1731632]
2.  Ichimura, M., Furuno, T., Takahashi, T., Dixon, R.A. and Ayabe, S. Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures. Phytochemistry 44 (1997) 991–995. [DOI] [PMID: 9055445]
[EC created 2004]

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