ExplorEnz: EC 2.1.1.166

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2.1.1.166

Accepted name:

23S rRNA (uridine²⁵⁵²-2′-O)-methyltransferase

Reaction:

S-adenosyl-L-methionine + uridine²⁵⁵² in 23S rRNA = S-adenosyl-L-homocysteine + 2′-O-methyluridine²⁵⁵² in 23S rRNA

Other name(s):

Um(2552) 23S ribosomal RNA methyltransferase; heat shock protein RrmJ; RrmJ; FTSJ; Um2552 methyltransferase

Systematic name:

S-adenosyl-L-methionine:23S rRNA (uridine²⁵⁵²-2′-O-)-methyltransferase

Comments:

The enzyme catalyses the 2′-O-methylation of the universally conserved U²⁵⁵² in the A loop of 23S rRNA [3].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Caldas, T., Binet, E., Bouloc, P., Costa, A., Desgres, J. and Richarme, G. The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase. J. Biol. Chem. 275 (2000) 16414–16419. [DOI] [PMID: 10748051]
2.	Hager, J., Staker, B.L., Bugl, H. and Jakob, U. Active site in RrmJ, a heat shock-induced methyltransferase. J. Biol. Chem. 277 (2002) 41978–41986. [DOI] [PMID: 12181314]
3.	Hager, J., Staker, B.L. and Jakob, U. Substrate binding analysis of the 23S rRNA methyltransferase RrmJ. J. Bacteriol. 186 (2004) 6634–6642. [DOI] [PMID: 15375145]
4.	Bugl, H., Fauman, E.B., Staker, B.L., Zheng, F., Kushner, S.R., Saper, M.A., Bardwell, J.C. and Jakob, U. RNA methylation under heat shock control. Mol. Cell 6 (2000) 349–360. [DOI] [PMID: 10983982]

[EC 2.1.1.166 created 2010]