ExplorEnz: EC 2.1.1.183

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2.1.1.183

Accepted name:

18S rRNA (adenine¹⁷⁷⁹-N⁶/adenine¹⁷⁸⁰-N⁶)-dimethyltransferase

Reaction:

4 S-adenosyl-L-methionine + adenine¹⁷⁷⁹/adenine¹⁷⁸⁰ in 18S rRNA = 4 S-adenosyl-L-homocysteine + N⁶-dimethyladenine¹⁷⁷⁹/N⁶-dimethyladenine¹⁷⁸⁰ in 18S rRNA

Other name(s):

18S rRNA dimethylase Dim1p; Dim1p; ScDim1; m2(6)A dimethylase; KIDIM1

Systematic name:

S-adenosyl-L-methionine:18S rRNA (adenine¹⁷⁷⁹-N⁶/adenine¹⁷⁸⁰-N⁶)-dimethyltransferase

Comments:

DIM1 is involved in pre-rRNA processing [1].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Lafontaine, D., Vandenhaute, J. and Tollervey, D. The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast. Genes Dev. 9 (1995) 2470–2481. [DOI] [PMID: 7590228]
2.	Lafontaine, D.L., Preiss, T. and Tollervey, D. Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis. Mol. Cell Biol. 18 (1998) 2360–2370. [DOI] [PMID: 9528805]
3.	Pulicherla, N., Pogorzala, L.A., Xu, Z., O'Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Sia, E.A., Culver, G.M. and Rife, J.P. Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases. J. Mol. Biol. 391 (2009) 884–893. [DOI] [PMID: 19520088]
4.	Lafontaine, D., Delcour, J., Glasser, A.L., Desgres, J. and Vandenhaute, J. The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3′-terminal loop of 18 S rRNA is essential in yeast. J. Mol. Biol. 241 (1994) 492–497. [DOI] [PMID: 8064863]
5.	O'Farrell, H.C., Pulicherla, N., Desai, P.M. and Rife, J.P. Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution. RNA 12 (2006) 725–733. [DOI] [PMID: 16540698]

[EC 2.1.1.183 created 1976 as EC 2.1.1.48, part transferred 2010 to EC 2.1.1.183]