The Enzyme Database

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Accepted name: tRNA (cytosine38-C5)-methyltransferase
Reaction: S-adenosyl-L-methionine + cytosine38 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA
Other name(s): hDNMT2 (gene name); DNMT2 (gene name); TRDMT1 (gene name)
Systematic name: S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase
Comments: The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Goll, M.G., Kirpekar, F., Maggert, K.A., Yoder, J.A., Hsieh, C.L., Zhang, X., Golic, K.G., Jacobsen, S.E. and Bestor, T.H. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science 311 (2006) 395–398. [DOI] [PMID: 16424344]
2.  Jurkowski, T.P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G. and Jeltsch, A. Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. RNA 14 (2008) 1663–1670. [DOI] [PMID: 18567810]
3.  Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M. and Lyko, F. RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage. Genes Dev. 24 (2010) 1590–1595. [DOI] [PMID: 20679393]
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