| EC |
2.1.1.206 |
| Accepted name: |
tRNA (cytidine56-2′-O)-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + cytidine56 in tRNA = S-adenosyl-L-homocysteine + 2′-O-methylcytidine56 in tRNA |
| Other name(s): |
aTrm56; tRNA ribose 2′-O-methyltransferase aTrm56; PAB1040 (gene name) |
| Systematic name: |
S-adenosyl-L-methionine:tRNA (cytidine56-2′-O)-methyltransferase |
| Comments: |
The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2′-O-ribose methylation of cytidine at position 56 in tRNA transcripts. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Renalier, M.H., Joseph, N., Gaspin, C., Thebault, P. and Mougin, A. The Cm56 tRNA modification in archaea is catalyzed either by a specific 2′-O-methylase, or a C/D sRNP. RNA 11 (2005) 1051–1063. [DOI] [PMID: 15987815] |
| 2. |
Kuratani, M., Bessho, Y., Nishimoto, M., Grosjean, H. and Yokoyama, S. Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2′-O-methylcytidine at position 56 of tRNA. J. Mol. Biol. 375 (2008) 1064–1075. [DOI] [PMID: 18068186] |
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| [EC 2.1.1.206 created 2011] |
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