| EC |
2.1.1.214 |
| Accepted name: |
tRNA (guanine10-N2)-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + guanine10 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA |
| Other name(s): |
(m2G10) methyltransferase; Trm11-Trm112 complex |
| Systematic name: |
S-adenosyl-L-methionine:tRNA (guanine10-N2)-methyltransferase |
| Comments: |
In contrast to the archaeal enzyme tRNA (guanine10-N2)-dimethyltransferase (EC 2.1.1.213), tRNA (guanine10-N2)-methyltransferase from yeast does not catalyse the methylation from N2-methylguanine10 to N2-dimethylguanine10 in tRNA. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Purushothaman, S.K., Bujnicki, J.M., Grosjean, H. and Lapeyre, B. Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. Mol. Cell Biol. 25 (2005) 4359–4370. [DOI] [PMID: 15899842] |
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| [EC 2.1.1.214 created 2011 (EC 2.1.1.32 created 1972, part transferred 2011 to EC 2.1.1.214)] |
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