The Enzyme Database

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Accepted name: [phosphatase 2A protein]-leucine-carboxy methyltransferase
Reaction: S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
Other name(s): leucine carboxy methyltransferase-1; LCMT1
Systematic name: S-adenosyl-L-methionine:[phosphatase 2A protein]-leucine O-methyltransferase
Comments: Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  De Baere, I., Derua, R., Janssens, V., Van Hoof, C., Waelkens, E., Merlevede, W. and Goris, J. Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue. Biochemistry 38 (1999) 16539–16547. [DOI] [PMID: 10600115]
2.  Tsai, M.L., Cronin, N. and Djordjevic, S. The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A. Acta Crystallogr. D Biol. Crystallogr. 67 (2011) 14–24. [DOI] [PMID: 21206058]
[EC created 2011]

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