| EC |
2.1.1.245 |
| Accepted name: |
5-methyltetrahydrosarcinapterin—corrinoid/iron-sulfur protein Co-methyltransferase |
| Reaction: |
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin |
| Other name(s): |
cdhD (gene name); cdhE (gene name) |
| Systematic name: |
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein methyltransferase |
| Comments: |
Catalyses the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin. Forms, together with EC 1.2.7.4, anaerobic carbon-monoxide dehydrogenase, and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, the acetyl-CoA decarbonylase/synthase complex that catalyses the demethylation of acetyl-CoA in a reaction that also forms CO2. This reaction is a key step in methanogenesis from acetate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Maupin-Furlow, J. and Ferry, J.G. Characterization of the cdhD and cdhE genes encoding subunits of the corrinoid/iron-sulfur enzyme of the CO dehydrogenase complex from Methanosarcina thermophila. J. Bacteriol. 178 (1996) 340–346. [DOI] [PMID: 8550451] |
| 2. |
Grahame, D.A. and DeMoll, E. Partial reactions catalyzed by protein components of the acetyl-CoA decarbonylase synthase enzyme complex from Methanosarcina barkeri. J. Biol. Chem. 271 (1996) 8352–8358. [DOI] [PMID: 8626532] |
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| [EC 2.1.1.245 created 2012] |
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