| EC |
2.1.1.253 |
| Accepted name: |
[methyl-Co(III) tetramethylammonium-specific corrinoid protein]—coenzyme M methyltransferase |
| Reaction: |
a [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) tetramethylammonium-specific corrinoid protein] |
| Glossary: |
CoM = coenzyme M = 2-sulfanylethane-1-sulfonate = 2-mercaptoethanesulfonate (deprecated) |
| Other name(s): |
methyltransferase 2 (ambiguous); mtqA (gene name) |
| Systematic name: |
methylated tetramethylammonium-specific corrinoid protein:CoM methyltransferase |
| Comments: |
The enzyme, which is involved in methanogenesis from tetramethylammonium, catalyses the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.252, tetramethylammonium—corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to CoM, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Asakawa, S., Sauer, K., Liesack, W. and Thauer, R.K. Tetramethylammonium:coenzyme M methyltransferase system from methanococcoides s. Arch. Microbiol. 170 (1998) 220–226. [PMID: 9732435] |
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| [EC 2.1.1.253 created 2012] |
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