The Enzyme Database

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Accepted name: 4-dimethylallyltryptophan N-methyltransferase
Reaction: S-adenosyl-L-methionine + 4-prenyl-L-tryptophan = S-adenosyl-L-homocysteine + 4-prenyl-L-abrine
For diagram of ergot alkaloid biosynthesis, click here
Glossary: 4-prenyl-L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan = 4-dimethylallyl-L-tryptophan (ambiguous);
4-prenyl-L-abrine = 4-(3-methylbut-2-enyl)-L-abrine = 4-dimethylallyl-L-abrine (ambiguous)
Other name(s): fgaMT (gene name); easF (gene name)
Systematic name: S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase
Comments: The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Rigbers, O. and Li, S.M. Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase. J. Biol. Chem. 283 (2008) 26859–26868. [DOI] [PMID: 18678866]
[EC created 2012]

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