The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 2.1.1.262     
Accepted name: squalene methyltransferase
Reaction: 2 S-adenosyl-L-methionine + squalene = 2 S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene (overall reaction)
(1a) S-adenosyl-L-methionine + squalene = S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene
(1b) S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene = S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene
For diagram of botryococcus braunii BOT22 squalene and botrycoccene biosynthesis, click here
Other name(s): TMT-1; TMT-2
Systematic name: S-adenosyl-L-methionine:squalene C-methyltransferase
Comments: Two isoforms differing in their specificity were isolated from the green alga Botryococcus braunii BOT22. TMT-1 gave more of the dimethylated form whereas TMT2 gave more of the monomethylated form.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Niehaus, T.D., Kinison, S., Okada, S., Yeo, Y.S., Bell, S.A., Cui, P., Devarenne, T.P. and Chappell, J. Functional identification of triterpene methyltransferases from Botryococcus braunii race B. J. Biol. Chem. 287 (2012) 8163–8173. [DOI] [PMID: 22241476]
[EC 2.1.1.262 created 2012]
 
 


Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald