ExplorEnz: EC 2.1.1.268

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2.1.1.268

Accepted name:

tRNA^Thr (cytosine³²-N³)-methyltransferase

Reaction:

(1) S-adenosyl-L-methionine + cytosine³² in tRNA^Thr = S-adenosyl-L-homocysteine + N³-methylcytosine³² in tRNA^Thr
(2) S-adenosyl-L-methionine + cytosine³² in tRNA^Ser = S-adenosyl-L-homocysteine + N³-methylcytosine³² in tRNA^Ser

Other name(s):

ABP140; Trm140p

Systematic name:

S-adenosyl-L-methionine:tRNA^Thr (cytosine³²-N³)-methyltransferase

Comments:

The enzyme from Saccharomyces cerevisiae specifically methylates cytosine³² in tRNA^Thr and in tRNA^Ser.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Noma, A., Yi, S., Katoh, T., Takai, Y., Suzuki, T. and Suzuki, T. Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. RNA 17 (2011) 1111–1119. [DOI] [PMID: 21518805]
2.	D'Silva, S., Haider, S.J. and Phizicky, E.M. A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop. RNA 17 (2011) 1100–1110. [DOI] [PMID: 21518804]

[EC 2.1.1.268 created 2013]