The Enzyme Database

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Accepted name: cobalt-factor III methyltransferase
Reaction: S-adenosyl-L-methionine + cobalt-factor III + reduced acceptor = S-adenosyl-L-homocysteine + cobalt-precorrin-4 + acceptor
For diagram of anaerobic corrin biosynthesis (part 1), click here
Other name(s): CbiH60 (gene name); S-adenosyl-L-methionine:cobalt-factor III 17-methyltransferase (ring contracting)
Systematic name: S-adenosyl-L-methionine:cobalt-factor III C17-methyltransferase (ring contracting)
Comments: Isolated from the bacterium Bacillus megaterium. The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17. Contains a [4Fe-4S] cluster. It can also convert cobalt-precorrin-3 to cobalt-precorrin-4. The reductant may be thioredoxin. See EC, precorrin-3B C17-methyltransferase, for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Moore, S.J., Biedendieck, R., Lawrence, A.D., Deery, E., Howard, M.J., Rigby, S.E. and Warren, M.J. Characterization of the enzyme CbiH60 involved in anaerobic ring contraction of the cobalamin (vitamin B12) biosynthetic pathway. J. Biol. Chem. 288 (2013) 297–305. [DOI] [PMID: 23155054]
[EC created 2013]

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