ExplorEnz: EC 2.1.1.281

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2.1.1.281

Accepted name:

phenylpyruvate C³-methyltransferase

Reaction:

S-adenosyl-L-methionine + 3-phenylpyruvate = S-adenosyl-L-homocysteine + (3S)-2-oxo-3-phenylbutanoate

Glossary:

3-phenylpyruvate = 2-oxo-3-phenylpropanoate
(3S)-2-oxo-3-phenylbutanoate = (3S)-β-methyl-phenylpyruvate

Other name(s):

phenylpyruvate Cβ-methyltransferase; phenylpyruvate methyltransferase; mppJ (gene name)

Systematic name:

S-adenosyl-L-methionine:2-oxo-3-phenylpropanoate C³-methyltransferase

Comments:

The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)-β-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

Huang, Y.T., Lyu, S.Y., Chuang, P.H., Hsu, N.S., Li, Y.S., Chan, H.C., Huang, C.J., Liu, Y.C., Wu, C.J., Yang, W.B. and Li, T.L. In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-β-methylphenylalanine in glycopeptide antibiotic mannopeptimycin. ChemBioChem 10 (2009) 2480–2487. [DOI] [PMID: 19731276]

[EC 2.1.1.281 created 2013]