| EC |
2.1.1.284 |
| Accepted name: |
8-demethylnovobiocic acid C8-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + 8-demethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid |
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For diagram of novobiocin biosynthesis, click here |
| Glossary: |
novobiocic acid = N-(2,7-dihydroxy-8-methyl-4-oxochromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl) benzamide |
| Other name(s): |
NovO |
| Systematic name: |
S-adenosyl-L-methionine:8-demethylnovobiocic acid C8-methyltransferase |
| Comments: |
The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Pacholec, M., Tao, J. and Walsh, C.T. CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis. Biochemistry 44 (2005) 14969–14976. [DOI] [PMID: 16274243] |
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| [EC 2.1.1.284 created 2013] |
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