The Enzyme Database

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Accepted name: aklanonic acid methyltransferase
Reaction: S-adenosyl-L-methionine + aklanonate = S-adenosyl-L-homocysteine + methyl aklanonate
For diagram of aflatoxin biosynthesis, click here
Glossary: methyl aklanonate = methyl [1,4,5-trihydroxy-9,10-dioxo-3-(3-oxopentanoyl)-9,10-dihydroanthracen-2-yl]acetate
aklanonate = [4,5-dihydroxy-9,10-dioxo-3-(3-oxopentanoyl)-9,10-dihydroanthracen-2-yl]acetic acid
Other name(s): DauC; AAMT
Systematic name: S-adenosyl-L-methionine:aklanonate O-methyltransferase
Comments: The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Dickens, M.L., Ye, J. and Strohl, W.R. Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5. J. Bacteriol. 177 (1995) 536–543. [DOI] [PMID: 7836284]
[EC created 2013]

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