The Enzyme Database

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Accepted name: cobalt-precorrin-7 (C5)-methyltransferase
Reaction: S-adenosyl-L-methionine + cobalt-precorrin-7 = S-adenosyl-L-homocysteine + cobalt-precorrin-8
For diagram of anaerobic corrin biosynthesis (part 2), click here
Other name(s): CbiE
Systematic name: S-adenosyl-L-methionine:precorrin-7 C5-methyltransferase
Comments: This enzyme catalyses the methylation at C-5 of cobalt-precorrin-7, a step in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway. The equivalent activity in the aerobic adenosylcobalamin biosynthesis pathway is catalysed by the bifunctional enzyme EC, precorrin-6B C5,15-methyltransferase (decarboxylating).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Santander, P.J., Kajiwara, Y., Williams, H.J. and Scott, A.I. Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B12 anaerobic pathway. Bioorg. Med. Chem. 14 (2006) 724–731. [DOI] [PMID: 16198574]
2.  Moore, S.J., Lawrence, A.D., Biedendieck, R., Deery, E., Frank, S., Howard, M.J., Rigby, S.E. and Warren, M.J. Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). Proc. Natl. Acad. Sci. USA 110 (2013) 14906–14911. [DOI] [PMID: 23922391]
[EC created 2010]

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