The Enzyme Database

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Accepted name: protein N-terminal monomethyltransferase
Reaction: S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein]
Other name(s): NRMT2 (gene name); METTL11B (gene name); N-terminal monomethylase
Systematic name: S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] monomethyltransferase
Comments: This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Petkowski, J.J., Bonsignore, L.A., Tooley, J.G., Wilkey, D.W., Merchant, M.L., Macara, I.G. and Schaner Tooley, C.E. NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1. Biochem. J. 456 (2013) 453–462. [DOI] [PMID: 24090352]
[EC created 2014]

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