The Enzyme Database

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Accepted name: phenazine-1-carboxylate N-methyltransferase
Reaction: S-adenosyl-L-methionine + phenazine-1-carboxylate = S-adenosyl-L-homocysteine + 5-methylphenazine-1-carboxylate
For diagram of enediyne antitumour antibiotic biosynthesis and pyocyanin biosynthesis, click here
Other name(s): phzM (gene name)
Systematic name: S-adenosyl-L-methionine:phenazine-1-carboxylate 5-methyltransferase
Comments: The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. The enzyme is active in vitro only in the presence of EC, 5-methylphenazine-1-carboxylate 1-monooxygenase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Parsons, J.F., Greenhagen, B.T., Shi, K., Calabrese, K., Robinson, H. and Ladner, J.E. Structural and functional analysis of the pyocyanin biosynthetic protein PhzM from Pseudomonas aeruginosa. Biochemistry 46 (2007) 1821–1828. [DOI] [PMID: 17253782]
[EC created 2016]

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