| EC |
2.1.1.328 |
| Accepted name: |
N-demethylindolmycin N-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + N-demethylindolmycin = S-adenosyl-L-homocysteine + indolmycin |
| Glossary: |
indolmycin = (5S)-5-[(1R)-1-(indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazolin-4(5H)-one |
| Other name(s): |
ind7 (gene name) |
| Systematic name: |
S-adenosyl-L-methionine:N-demethylindolmycin N-methyltransferase |
| Comments: |
The enzyme, characterized from the bacterium Streptomyces griseus, catalyses the ultimate reaction in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan—tRNA ligase (EC 6.1.1.2). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Du, Y.L., Alkhalaf, L.M. and Ryan, K.S. In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly. Proc. Natl. Acad. Sci. USA 112 (2015) 2717–2722. [DOI] [PMID: 25730866] |
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| [EC 2.1.1.328 created 2016] |
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