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Your query returned 1 entry. 
Printable version
| EC | 2.1.1.330 | ||
| Accepted name: | 5′-demethylyatein 5′-O-methyltransferase | ||
| Reaction: | S-adenosyl-L-methionine + (–)-5′-demethylyatein = S-adenosyl-L-homocysteine + (–)-yatein | ||
| For diagram of podophyllotoxin biosynthesis, click here | |||
| Glossary: | (–)-5′-demethylyatein = (3R,4R)-4-(2,3-benzodioxol-5-ylmethyl)-3-(3-hydroxy-4,5-dimethoxybenzyl)dihydrofuran-2(3H)-one (–)-yatein = (3R,4R)-4-(1,3-benzodioxol-5-ylmethyl)-3-(3,4,5-trimethoxybenzyl)dihydrofuran-2(3H)-one |
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| Other name(s): | OMT1 (gene name) | ||
| Systematic name: | S-adenosyl-L-methionine:(–)-5′-demethylyatein 5′-O-methyltransferase | ||
| Comments: | The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. | ||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
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