| EC |
2.1.1.38 |
| Accepted name: |
O-demethylpuromycin O-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin |
| Other name(s): |
O-demethylpuromycin methyltransferase |
| Systematic name: |
S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase |
| Comments: |
Puromycin is the antibiotic derived from N6-dimethyladenosine by replacing the 3′-hydroxy group with an amino group and acylating this with 4-O-methyltyrosine. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 37257-04-8 |
| References: |
| 1. |
Rao, M.M., Rebello, P.F. and Pogell, B.M. Biosynthesis of puromycin in Streptomyces alboniger. Enzymatic methylation of O-demethylpuromycin. J. Biol. Chem. 244 (1969) 112–118. [PMID: 5773275] |
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| [EC 2.1.1.38 created 1972] |
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