ExplorEnz: EC 2.1.1.397

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2.1.1.397

Accepted name:

hydroxystrychnine O-methyltransferase

Reaction:

S-adenosyl-L-methionine + 10-hydroxystrychnine = S-adenosyl-L-homocysteine + β-colubrine

Glossary:

β-colubrine = 2-methoxystrychnidin-10-one = (4aR,5aS,8aR,13aS,15aS,15bR)-10-methoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
10-hydroxystrychnine = 2-hydroxystrychnidin-10-one

Systematic name:

S-adenosyl-L-methionine:hydroxystrychnine O-methyltransferase

Comments:

The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine. It can methylate 10-hydroxystrychnine, and, with lower efficiency, 11-hydroxystrychnine and 11-demethylbrucine.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Hong, B., Grzech, D., Caputi, L., Sonawane, P., Lopez, C.ER., Kamileen, M.O., Hernandez Lozada, N.J., Grabe, V. and O'Connor, S.E. Biosynthesis of strychnine. Nature 607 (2022) 617–622. [DOI] [PMID: 35794473]

[EC 2.1.1.397 created 2024]