| EC |
2.1.1.403 |
| Accepted name: |
methylecgonone synthase |
| Reaction: |
S-adenosyl L-methionine + ecgonone = S-adenosyl-L-homocysteine + ecgonone methyl ester
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| Glossary: |
ecgonone = (1R,2R,5S)-8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Other name(s): |
MT4 |
| Systematic name: |
S-adenosyl-L-methionine:ecgonone O-methyltransferase |
| Comments: |
Isolated from the plant Erythroxylum novogranatense. The enzyme, which is highly stereoselective, is involved in cocaine biosynthesis. The substrate, ecgonone, is unstable, and in the absence of the methyltransferase decarboxylates into tropinone. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Wang, Y.J., Huang, J.P., Tian, T., Yan, Y., Chen, Y., Yang, J., Chen, J., Gu, Y.C. and Huang, S.X. Discovery and engineering of the cocaine biosynthetic pathway. J. Am. Chem. Soc. 144 (2022) 22000–22007. [DOI] [PMID: 36376019] |
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| [EC 2.1.1.403 created 2025] |
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